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Thalidomide Behçet's disease

Side effects were uncommon and included skin rash and somnolence. These results suggest that thalidomide may be useful in the therapy of the various manifestations of Behçet's disease and that a controlled study is indicated Thalidomide in adult Behçet's disease Reports of the use of thalidomide for BD first appeared in 1982 26, 27 including one by Saylan and Saltik 〚28〛. The majority of their patients treated with thalidomide showed resolution of oral lesions. However, there was no improvement in eye involvement or arthritis

Treatment of Behçet's disease with thalidomid

  1. Background: Thalidomide has been identified and its anti-inflammatory and immunomodulatory properties clarified. This report expands our report of 2 entero-Behçet disease children who developed significant steroid toxicity and improved dramatically with thalidomide
  2. ed, is the most active medicament in particularly severe cases with profusion of necrotic aphthae, mutilating and recurring mucocutaneous aphthosis, also being useful in controlling some symptoms of Behçet's disease
  3. and by the World Health Organization (1994). Recently, thalidomide has been studied in a wide variety of inflammatory and immunologic disorders including chronic graft-versus-host disease, rheumatoid arthritis, inflammatory bowel disease, lichen planus, Behcet's disease, pyoderma gangrenosum, sarcoidosis
  4. or improvement of th
  5. In this study, the effects of thalidomide on peripheral CD4+CD45RO+ memory T and γδ+ T cells later in BD. blood mononuclear cells were investigated ex vivo. In an open prospective study, ten patients were given 200 mg/day Keywords Behcet's disease

Behçet's disease (BD) is a chronic systemic autoinflammatory disease whose treatment can be challenging and is dependent on disease expression and symptoms.Thalidomide can be effective for treating recurrent oral aphthae, but its use is limited by adverse effects, mostly sensory polyneuropathy.Lenalidomide is a more powerful thalidomide analogue with fewer adverse effects and may be effective for the treatment of BD In Behçet's disease, thalidomide 100 to 300 mg/day can decrease the number of mucocutaneous ulcers, although full remission occurs in less than 20% of patients. In Crohn's disease, thalidomide 50 to 300 mg/day may decrease the severity of mucosal disease and prompt closure of fistulae The clinical response to thalidomide in 30 male patients with Behçet's disease was reviewed. Twenty-six patients with orogenital ulcerations responded (20 completely and 6 partially). Cutaneous lesions including erythema nodosum or necrotic pseudofolliculitis were controlled by treatment in the majority of cases Treatment of recurrent perforating intestinal ulcers with thalidomide in Behçet's disease. Sayarlioglu M (1), Kotan MC, Topcu N, Bayram I, Arslanturk H, Gul A

Thalidomide is a recognized treatment of Behçet's disease. Low-dose thalidomide seems to be effective in the treatment of orogenital ulcers and is potentially safer with a lower incidence of adverse effects than higher doses. We wish to report a case of Behçet's disease in a 33-year-old woman who responded well to thalidomide 50 mg 2 to 4. International Study Group for Behçet's Disease (1990) Criteria for diagnosis of Behçet's disease. Lancet 335:1078-1080. Google Scholar 12. Moriera AL, Sampaio EP, Zmuidzinas A et al (1993) Thalidomide exerts its inhibitory action on tumor necrosis factor-α by enhancing m-RNA degradation. J Exp Med 177:1675-168 Key words: Behçet's disease, Behçet's syndrome, management, intestinal involvement, inflammatory bowel disease, infliximab, etanercept, adalimumab, thalidomide Competing interests: none declared. ABSTRACT Objective. Gastrointestinal involvement of Behçet's syndrome is usually treated with glucocorticoids, 5-aminosalicyl Thalidomide has been used in refractory cases but its use is limited giving its adverse effects. Apremilast is an emerging drug for the use of oral ulcers. Ocular inflammatory disease. Venous disease in Behçet's syndrome is believed to result from endothelial inflammation leading to thrombosis. The treatment approach of preventing venous. Behçet disease (BD) has also been treated with thalidomide. [ 1 3 , 20 , 21 , 22 ] BD is a type of systemic vasculitis with recurrent oral and genital ulcers, skin lesions (papules, pustules, or erythema nodosum lesions), panuveitis, or arthritis

Thalidomide in Behçet's disease - ScienceDirec

Thalidomide for treatment of intestinal involvement of

Three patients suffered a thromboembolism at a mean cumulative dose of 6.9 ± 2.3 g and after a median thalidomide treatment duration of 8 months (range, 1-12 mo): 2 patients with Behçet disease developed deep venous thromboses of the lower limbs, and a 34-year-old patient suffered an ischemic stroke of unknown etiology BD in children is similar to the disease in adults. Thalidomide provided a useful therapeutic option for severe oral and genital ulceration which was unresponsive to other therapies. Awareness of the danger of axonal neuropathy and teratogenesis at all times during thalidomide therapy is crucial Abstract: We describe an 11‐month‐old child with giant ulcers of the buccal mucosa, necrosis of the tongue, abdominal tenderness, and severe diarrhea due to Behçet disease. Treatment with thalidomide..

Abstract Behçet's disease is a chronic relapsing inflammatory disorder characterized by oral and genital ulcers, skin lesions, and uveitis. Although the involvement of the gastrointestinal, large vascular, and central nervous systems is less common, it can be fatal at times Thalidomide has also been used to treat Behcets disease (an immune system induced vascular condition where vessels are destroyed causing bleeding and tissue damage), as well as graft versus host. To report the beneficial effects of thalidomide on recurrent perforating intestinal ulcers in a patient with Behçet's disease (BD). CASE SUMMARY A 24-year-old Turkish woman with BD was admitted to our hospital because of severe abdominal pain and vomiting Behçet's disease (BD) is a rare relapsing systemic inflammatory disorder of unknown etiology characterized by recurrent oral ulcers, genital sores, and ocular lesions; however many other organs including the vascular, neurological, and musculoskeletal systems as well as the gastrointestinal system can be involved [ 1 -

[Thalidomide in the treatment of aphthosis and Behçet's

Thalidomide - Behcet'

The aim of treatment in Behçet disease (BD) is to prevent irreversible damage that mostly occurs early in the course of disease, especially in the high-risk group, young men,1 2 and to prevent exacerbations of mucocutaneous and joint involvement, usually not causing damage but affecting quality of life. The multisystem involvement mandates collaboration between different specialties After 5 months as an out-patient his condition is still satisfactory and without symptoms of his former disease. Thalidomide has previously been reported to be of value in treatment of Behçet's syndrome, but to my knowledge never with such a dramatic effect on a severe colitis as reported in this case Behçet's disease are often indistinguishable from similar lesions occurring in other conditions. For instance, the erythema nodosum-like lesions of Behçet's of follicular lesions with thalidomide 100-300 mg daily.6 An open-label study in 30 patients found that indomethacin 25 mg four time Behçet's (bay-setz) Disease is a rare disease that causes inflammation of many parts of the body. These include the skin of the genital area, lining of the mouth, eye, nervous system, joints and blood vessels. The most characteristic problems include ulcers in the mouth and genital areas, and serious eye inflammation Behçet disease (or syndrome) is a rare disease characterised by painful mouth ulcers, genital ulcers, eye problems and skin lesions. The condition is named after the Turkish dermatologist Hulusi Behçet who first described the disease in 1924. It is also known as Adamantiades-Behçet disease

[Erythroleukemia in a patient with Behçet's disease under long-term thalidomide therapy]. Louzir B, Othmani S, Gritli N, Beji M, Zidi B, M'Saddek F, Boussema E, Bahri M. Annales de Medecine Interne, 01 Jan 1992, 143(7): 479-480 Language: fre PMID: 1300872 . Share this article Share with email. Introduction:Behçet's disease (BD) is a chronic systemic condition characterized by recurrent oral and genital ulcers, neurological and vascular manifestations, ocular and skin lesions, and a positive pathergy test. Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome is rare and consists of features of BD together with relapsing polychondritis Behçet disease is an inflammatory disorder that can include a vasculitis of small and large arteries and/or veins. Arterial and venous thrombosis may occur as well. The disease occurs nearly equally in men and women but tends to be more severe in men, typically beginning during their 20s Behçet disease is characterized by a triple-symptom complex of recurrent oral aphthous ulcers, genital ulcers, and uveitis. Hippocrates may have described Behçet disease in the fifth century BCE; however, the first description of the syndrome was attributed to the Turkish dermatologist Hulusi Behçet in 1924 Behcet disease, also known as an oculo-orogenital syndrome, is a chronic remitting and relapsing inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcerations, ocular manifestations, and other systemic involvement. It is also called Behcet syndrome and Malignant aphthosis

Treatment of colitis in Behçet's disease with thalidomide

• Behçet's disease (BD) is a chronic systemic autoinflammatory disease whose treatment can be challenging and is dependent on disease expression and symptoms. • Thalidomide can be effective for treating recurrent oral aphthae, but its use is limited by adverse effects, mostly sensory polyneuropathy A second case report in a patient with both Behçet disease and CRPS showed resolution of the CRPS pain after administration of thalidomide at a dose of 100-400 mg/day was started. 86 Schwartzmann et al. wrote an editorial on their clinical experience using thalidomide in 42 patients, of which 13 (31%) had moderate to excellent pain relief 1. DOI: 10.1007/-306-48382-3_119 Corpus ID: 36048884. Therapeutic effect of thalidomide through cytokine and chemokine regulation in herpes simplex virus-induced Behçet's disease-like animal model Behçet's Disease. Behçet's disease (BD) is a rare immune disorder that causes inflammation of the blood vessels. It can affect both arteries and veins of any size. The most common symptoms are sores in the mouth and/or genitals but it can also affect the skin, eyes (causing the conditions iritis or uveitis), joints (arthritis) and other organs..

(PDF) Thalidomide has both anti-inflammatory and

Medicine by Sfakianakis G

Adamantiades-Behçet's Disease. It is with great pleasure that I write this Foreword to the Proceedings of the International Conference on Behçet's Disease which was held in Berlin in June 2002. This was the first International Conference held under the auspices of the International Society for Behçet's Disease which was founded in 2000. Behçet's disease-Wikipedia A long-running issue during his tenure was thalidomide, a drug prescribed to expectant mothers suffering from morning sickness , which led to thousands of children in Britain having deformed limbs

Lenalidomide: An Alternative Treatment for Refractory

thalidomide and cell-mediated immunity in behcets-disease: 0: 2 1802: 0: 0: 943 1987 deutsche medizinische wochenschrift 112(9):365-365 lenz w thalidomide-caused birth-defects: 0: 0 1803: 3: 38: 944 1987 european journal of pediatrics 146(1):63-67 schafer kh; kramer m infantile hypertrophic pyloric-stenosis after prenatal exposure to. thalidomide and thalidomide with colchicine in the treatment of aphthosis, recurrent mucocutaneous aphthae and behcets-disease: 8: 16 115: 0: 2: 115 1984 gastroenterologie clinique et biologique 8(2):196-196 roge j; testas p thalidomide in behcets syndrome: 6: 7 116: 1: 33: 116 1984 geburtshilfe und frauenheilkunde 44(4):243-248 muhlenstedt d.

Colchicine (up to 1.5 to 2 mg/day) is sometimes effective for the treatment of mild oral and genital ulcers in Behçet's syndrome. Thalidomide (100 mg/day) is also useful for mucocutaneous disease manifestations. Low-dose glucocorticoids are also effective for intransigent mucocutaneous disease and may have a better side effect profile than. Behçet disease should be suspected in young adults with recurrent oral aphthous ulcers, unexplained ocular findings, or genital ulcers. Diagnosis of Behçet disease is clinical and often delayed because many of the manifestations are nonspecific and can be insidious OBJECTIVE To study the clinical spectrum of Behçet's disease (BD) in childhood, and to report our experience of using thalidomide. METHOD Ten children, diagnosed with BD, were studied retrospectively. RESULTS The median (range) age at first presentation was 4 (1.2-12.0) yr, at diagnosis was 11 (3-15) yr and the follow-up period was 4.1 (0.6-6.3) yr. Oral ulcers were present in all patients. At the end of follow-up, 87% of patients were still receiving ustekinumab. In four patients, the drug was stopped at month 3 due to headaches in one patient and a Behçet's disease flare in three patients. The researchers concluded that ustekinumab appears to be efficient and safe for oral ulcers, but that placebo-controlled studies are needed

Introduction. Behçet syndrome (BS) is a relapsing, multisystem inflammatory vasculitis characterized by oral (OU) and genital ulcers (GU), as well as involvement of the joints, ocular, vascular, nervous, and gastrointestinal systems. For many years, BS was thought to be an autoimmune disease To the Editor.— In the May 1979 Archives (115:636-637), Mascaro et al described the beneficial effect of thalidomide in the treatment of recurrent, necrotic, and giant mucocutaneous aphthae and aphthosis. They recorded excellent results in six patients while they were receiving a dosage of 100 mg/day. At about the time of this publication, we received a letter from A. C. McDougall, MD, MRCP. Thalidomide is a medication with strong anti‐inflammatory, immunomodulatory, antiangiogenic, and sedative properties. Recently, the successful application of thalidomide in several dermatological and hematological disorders inspired us to investigate its potential as an adjuvant treatment for PNP. Behçet's disease, or lichen planus has. A comment on this article appears in Mucocutaneous lesions in the Behçet syndrome. Ann Intern Med. 1998 Nov 15;129(10):836. A comment on this article appears in Behçet disease and the emergence of thalidomide. Ann Intern Med. 1998 Mar 15;128(6):494-5

Thalidomide has been accepted as an immunomodulatory drug in refractory pediatric autoimmune diseases such as Behcet's disease and systemic onset juvenile idiopathic arthritis [8, 9]. It has been demonstrated that thalidomide selectively inhibits the TNF-alpha and IL-6 mRNA expression in human peripheral blood mononuclear cells [ 10 ] Thalidomide [6, 7] p.o. 100-300 mg/day CNS involvement occurs more frequently in patients with Behçet's disease under cyclosporin A (CSA) than under other medications—results of a retrospective analysis of 117 cases. Clin Rheumatol Behçet's disease affects different parts of the body, therefore, a patient probably will see several different doctors. It may be helpful to both the doctors and the patient for one doctor to manage the complete treatment plan. Thalidomide - Thalidomide is an oral medication used for treating the skin conditions of leprosy, a disease. Behçet disease and the emergence of thalidomide. Ann Intern Med 1998; 128:494. Hamuryudan V, Mat C, Saip S, et al. Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome Thalidomide may have a role in treating severe, disabling conditions that do not respond to standard anti-inflammatory and immunosuppressive therapies. Behçet's disease, graft-versus-host.

Thalidomide is also being investigated for treating symptoms of prostate cancer, glioblastoma, lymphoma, arachnoiditis, Behçet's disease, and Crohn's disease. In a small trial, Australian researchers found thalidomide sparked a doubling of the number of T cells in patients, allowing the patients' own immun cutaneous manifestations of Behçet's disease, Crohn's disease, and lupus in children; however, the recurrence of disease is almost universal on drug discontinuation. CONCLUSIONS: Thalidomide should be used as a last resort when all other therapies fail, preferably in male or prepubescent female patients

Several new treatment modalities with different mechanisms of action have been studied in patients with Behçet's syndrome (BS). The aim of the current effort was to update the recommendations in the light of these new data under the auspices of the European League Against Rheumatism (EULAR) Standing Committee for Clinical Affairs. A task force was formed that included BS experts from. Thalidomide, sold under the brand names Contergan and Thalomid among others, is a medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy. While it has been used in a number of HIV-associated conditions, such use is associated with increased levels of the virus

Thalidomide in gastrointestinal disorders

Whilst thalidomide has been used for Behçet's syndrome in the past, it is now only very rarely used as other drugs are both more effective and are safer. For information on other drugs used in the treatment of vasculitis see Glossary of drugs and side effects Behçet's syndrome. Behçet's syndrome (bay-setz) n. a recurrent disease, involving many body systems, characterized by oral and genital ulceration and inflammation of the iris; skin lesions occur in most cases. It may also involve the joints and cause inflammation of the veins Behçet's Disease (BD) is a rare, idiopathic, chronic, relapsing, occlusive vasculitis involving arteries and veins of all caliber. As a result, it causes various ocular and systemic manifestations. The first report of this disease was made in 1931 by Greek ophthalmologist, Adamantiades, who described a patient with recurrent iritis, hypopyon. The disease associated HLA-B*51 and the closely related but disease-unassociated HLA-B52 molecules differ in two amino acid positions located in an antigen-binding pocket of the HLA groove. This suggests a direct role of the HLA-molecule itself in the susceptibility to Behcet's disease, and implies a role for extrinsic agents Current literature is looking at the effects of thalidomide for treating and preventing ulcerations in the mouth and genitals. Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients [ view article in Oxford Journal

Behçet disease is chronic blood vessel inflammation (vasculitis) that can cause painful mouth and genital sores, skin lesions, and eye problems. The joints, nervous system, and digestive tract may also become inflamed. Typically, sores appear, disappear, and reappear in the mouth and on the genitals and skin Behçet's syndrome or Behçet's disease (pronounced betchets) is a condition that causes a number of symptoms, including: mouth ulcers. genital ulcers. eye inflammation. It's named after Professor Hulusi Behçet a Turkish skin specialist, who first suggested these symptoms might all be linked to a single disease Behçet's disease (BD) is a chronic relapsing and remitting vasculitis of unknown aetiology. It has the capacity to affect almost all organ systems because of its potential to involve both arteries and veins of all sizes, resulting in significant organ-threatening morbidity and mortality. Traditionally known as the 'silk road' disease, it has a worldwide occurrence Behçet's disease (BD) is a systemic inflammatory disease involving primarily the oral and genital mucosa, skin and eyes. BD includes a vasculitis affecting all sizes of vessels but prominently the veins; thus, it was recently reclassified as variable type, [1, 2].The onset is insidious with peak age of onset in young adulthood (25-30 years), but also occasionally in children before the. Behçet disease is a multisystem, relapsing, chronic vasculitic disorder with mucosal inflammation. Common manifestations include recurrent oral ulcers, ocular inflammation, genital ulcers, and skin lesions. The most serious manifestations are blindness, neurologic or gastrointestinal manifestations, venous thromboses, and arterial aneurysms

Treatment of Behçet's disease with thalidomide SpringerLin

behcets disease 1. Presentor:Dr Chanabasayya Viraktamath Moderator:Dr Sukumar D 2. Historical aspects: In 1937, Prof. Hulusi Behçet, a Turkish dermatologist (1889- 1948), described a syndrome characterized by recurrent oral ulcers, genital ulcers, & hypopyon uveitis of unknown cause Thalidomide (α-phthalimidoglutarimide) is a derivative of glutamic acid, which is formulated as a 1:1 racemic mixture of S and R isomers. The S isomer provides immunomodulatory effects, whereas the R isomer has the sedative effects and is associated with teratogenicity (phocomelia and amelia) . Thalidomide is well absorbed orally, maximal plasma levels being reached in 2 to 4 hours Overview of Behçet's Disease. Behçet's disease is a chronic condition that causes mouth or genital sores, and inflammation in parts of the eye. In some people, the disease also produces arthritis (swollen, painful, stiff joints), skin problems, and inflammation of the digestive tract, brain, or spinal cord. Thalidomide therapy. Behcet's disease is an inflammatory disorder characterized by the presence of oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. Behзet's disease is an inflammatory disorder of unknown cause. There is a striking geographical distribution, it being most common in Turkey, Iran and Japan. The prevalence per 100 000 is 10-15 in. Behçet's disease is an inflammatory disorder of unknown cause. There is often involvement of the gastrointestinal system, the central nervous system and large vessels, which can be life-threatening. As well, ocular lesions can cause blindness. Mucocutaneous symptoms are self-limiting but more frequent

Ulcerative lesions in Behcet's disease (BD) are regarded as important manifestation for diagnosis. Various kinds of ulcerative lesions appear in patients with BD. They present as orogenital ulcers, necrotizing vasculitis and pyoderma gengrenosum. Gastrointestinal system involvement (Gis) in Behçet's disease affects all areas from the esophagus to the anus Behçet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been shown to. Thirteen (72%) of the 18 patients receiving immunosuppressives for eye disease had signs of eye disease at the time of entry to the thalidomide trial and 10 (77%) of them were YO patients. The first ocular attack causing more than two lines drop in visual acuity had occurred at a mean (S.D.) of 2.3 (4.7) years during the post-trial follow-up

What is Behçet’s disease?

Treatment of recurrent perforating intestinal ulcers with

4. Behçet's disease (BEH-chets) • Also called Behçet's syndrome, Morbus Behçet, or Silk Road disease, is a rare immune-mediated systemic vasculitis. • Behçet's disease (BD) was named in 1937 after the Turkish dermatologist Hulusi Behçet, who first described the triple-symptom complex of -recurrent oral aphthous ulcers, -genital. Update on the diagnosis and management of Behçet's disease Ryo Rokutanda, Mitsumasa Kishimoto, Masato Okada Immuno-Rheumatology Center, St Luke's International Hospital, Tokyo, Japan Abstract: Behçet's disease is a multi-organ disorder that is more common in countries around the Silk Road, and manifests as mucosal ulcers and skin lesions, and with ocular involvement Behçet's disease (BD) is a chronic systemic inflammatory disorder at the crossroad between autoimmune and autoinflammatory syndromes [ 2 ]. International criteria of classification have been defined with a sensitivity of 85% and specificity of 96% [ 3] (Table 1 ). Table 1 International Classification Criteria Of Behcet's Disease TNF alpha and response of treatment-resistant adult-onset Still's disease to thalidomide: 10: 25; 225: 22: 32: 809 1999 GASTROENTEROLOGY 117(6):1485-1488 Sands BE; Podolsky DK New life in a sleeper: Thalidomide and Crohn's disease: 8: 25; 226: 18: 36: 1317 2002 BLOOD 99(3):834-83

Master Rosina Marzo 09 [2]

Successful Treatment With Low-Dose Thalidomide in a

behcets-disease, palmoplantar pustulosis and hla-b27 treatment with thalidomide: 8: 9 662: 0: 5: 50 1982 nouvelle presse medicale 11(14):1080-1081 hamza m; chaffai m; benayed h treatment of behcets-disease with thalidomide: 9: 15 663: 0: 0: 206 1987 clinical rheumatology 6(4):608-609 hamza m; hamzaoui k; ayed k; eleuch m; zribi Diagnosis of Behçet's disease: It is a clinical diagnosis. There is no specific diagnostic test except for the pathergy test. Pathergy test: It is specific to Behçet's disease. Pricking the skin with a needle leads to the development of pustular lesion within 24-48 hours. ESR and CRP are usually elevate INTRODUCTION. Behçet's disease (BD), originally described in 1937 by the Turkish dermatologist Hulusi Behçet 1 as a distinct disease with orogenital ulceration and uveitis known as the triple-symptom complex, is an idiopathic chronic relapsing multisystem vascular-inflammatory disease of unknown origin. The disease affects many organs and systems, causing mucocutaneous lesions, eye.

Complex aphthosis: A large case series with evaluation

This is the first time official guidelines were compiled for neuro- Behcets. 11. Kansu T, Kirkali P, Kansu E, Zileli T. Optic neuropathy in Behçet's disease. J Clin Neuroophthalmol. 1989;9:277-80. PubMed CAS Google Scholar 12. Kidd D. The prevalence of headache in Behçet's syndrome. Rheumatology. 2006;45:621-3 Thalidomide Rx. Last updated: October 23, 2014. Trade Names: Thalomid. Drug Class: Immunomodulator. Preparations: Capsule: 50-, 100-, 150-, 200 mg. Dose: 100-300 mg daily in divided doses; must only be administered in compliance with the REMS program. Indications: Erythema nodosum leprosum, myeloma, small, mostly uncontrolled reports have. Behçet's disease (BD) is a type of inflammatory disorder which affects multiple parts of the body. The most common symptoms include painful mouth sores, genital sores, inflammation of parts of the eye, and arthritis. The sores typically last a few days. Less commonly there may be inflammation of the brain or spinal cord, blood clots, aneurysms, or blindness Behçet's disease is a chronic, recurrent, multisystemic, inflammatory disorder affecting mainly the oral and urogenital mucosa and the uveal tract. Although the etiology and pathogenesis of Behçet's disease are unknown, numerous etiologies have been proposed, including environmental, infectious, and immunological factors; an autoimmune basis, characterized by circulating immune complexes and. Thalidomide has one of the most notorious drug histories because of its teratogenicity. Its widespread use in the 1960s led to a worldwide epidemic of phocomelia in inborns; this in turn led to its complete ban in most of the world. However, it has now been licensed for selected indications including graft-versus-host-disease (GVHD) after bone marrow transplantation, wasting associated with. Behcet's disease is a systemic disorder characterized by recurrent aphthous stomatitis, genital ulceration, and iridocyclitis [].A new diagnosis criterion was recently proposed by a collaborative study of 27 countries [].Cardiovascular involvement in Behçet's disease is serious and its incidence is little documented